A mushroom cloud is a distinctive mushroom-shaped flammagenitus cloud of debris, smoke and usually condensed water vapor resulting from a large explosion. The effect is most commonly associated with a nuclear explosion, but any sufficiently energetic detonation or deflagration will produce the same effect. They can be caused by powerful conventional weapons, like thermobaric weapons such as the ATBIP and GBU-43/B MOAB. Some volcanic eruptions and impact events can produce natural mushroom clouds.

Mushroom clouds result from the sudden formation of a large volume of lower-density gases at any altitude, causing a Rayleigh–Taylor instability. The buoyant mass of gas rises rapidly, resulting in turbulent vortices curling downward around its edges, forming a temporary vortex ring that draws up a central column, possibly with smoke, debris, condensed water vapor, or a combination of these, to form the "mushroom stem". The mass of gas plus entrained moist air eventually reaches an altitude where it is no longer of lower density than the surrounding air; at this point, it disperses, drifting back down (see fallout). The stabilization altitude depends strongly on the profiles of the temperature, dew point, and wind shear in the air at and above the starting altitude.